What is Major Depressive Disorder (MDD)

What is Major Depressive Disorder (MDD)

What is Major Depressive Disorder (MDD) 1920 1280 ABVC

What is Major Depressive Disorder (MDD)

Major Depressive Disorder (MDD), also known as clinical depression, is a mental health condition characterized by persistent and severe symptoms that can significantly impact a person’s daily life. Living with Major Depressive Disorder (MDD) can be an overwhelming and challenging experience. Each day can feel like an uphill battle, as even the simplest tasks can become monumental struggles. It can often make it difficult to find joy or interest in things that used to bring happiness.

Identifying MDD

MDD can come in several forms, and symptoms can vary in severity and duration from person to person. Here are the five most common symptoms to be aware of when identifying MDD.

1.           Persistent Sadness or Low Mood: Individuals with MDD often experience a pervasive sense of sadness, hopelessness, or emptiness that lasts for most of the day, nearly every day.

2.           Loss of Interest or Pleasure: A diminished interest or pleasure in previously enjoyed activities, including hobbies, social interactions, and relationships, is a hallmark symptom of MDD.

3.           Fatigue and Lack of Energy: People with MDD often report feeling chronically tired, even after a whole night’s sleep. This fatigue can be physical and mental, making it difficult to carry out daily tasks.

4.           Changes in Appetite or Weight: Significant changes in appetite and weight are familiar with MDD. Some individuals may experience increased appetite and weight gain, while others may have decreased appetite and unintentional weight loss.

5.           Difficulty Concentrating and Making Decisions: MDD can impair cognitive functions such as concentration, memory, and decision-making. Individuals may struggle to focus on tasks, make simple choices, or complete work or school assignments.

Additionally, MDD may be associated with other symptoms such as sleep disturbances, guilt or worthlessness, physical aches and pains, and recurrent thoughts of death or suicide. 

What causes MDD?

The exact cause of Major Depressive Disorder (MDD) is not fully understood, as it is a complex condition that can result from a combination of various factors. Researchers believe that MDD is likely caused by biological, genetic, environmental, and psychological factors. Here are some key factors that may contribute to the development of MDD:

Brain Chemistry: An imbalance in neurotransmitters, such as serotonin, dopamine, and norepinephrine, is often associated with depression. These chemicals play a role in regulating mood, and their dysfunction can contribute to depressive symptoms.

Hormonal Changes: Hormonal fluctuations, such as those that occur during puberty, pregnancy, postpartum, and menopause, can influence mood and may trigger depression in susceptible individuals.

Genetics: There appears to be a genetic component to depression. People with a family history of depression are at a higher risk of developing MDD.

Stressful Life Events: Traumatic or highly stressful events, such as losing a loved one, relationship problems, financial difficulties, or job loss, can contribute to the onset of depression.

Chronic Illness: Certain medical conditions, chronic pain, or physical illnesses can increase the risk of developing MDD.

Substance Abuse: The misuse of drugs or alcohol can lead to or exacerbate depressive symptoms.

Personality Traits: Certain personality traits, such as a pessimistic outlook, low self-esteem, or a tendency to ruminate on negative thoughts, may increase the vulnerability to depression.

Psychological Trauma: Past experiences of trauma, abuse, or neglect can be a contributing factor.

Treatment options for MDD

Treatment options for Major Depressive Disorder (MDD) encompass a range of approaches tailored to the individual’s needs and the severity of their condition. Psychotherapy, particularly cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT), is a cornerstone of treatment. These therapies help individuals identify and change negative thought patterns, develop coping strategies, and improve interpersonal relationships. In more severe cases or when therapy alone is insufficient, antidepressant medications may be prescribed, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Lifestyle modifications, including regular exercise, a balanced diet, and adequate sleep, are essential to managing MDD. Support from a robust social network, participation in support groups, and self-help strategies can provide additional assistance. Overall, the most effective treatment often involves a combination of these approaches, and individuals must work closely with mental health professionals to find the right combination for their unique situation. With appropriate treatment and support, many individuals with MDD can achieve significant symptom relief and improve their quality of life.

If you or someone you know is experiencing symptoms of MDD, seeking help from a mental health professional is crucial, as effective treatments are available. Depression is a treatable condition, and with the proper support, many individuals can experience significant improvement in their quality of life.


The Insights Corner is a place to host blogs, video content, and more from the doctors and scientists here at ABVC. We’re developing a suite of medical devices and natural medicines derived from plants to address unmet medical needs.

Content on the ABVC website and Insights Corner, including but not limited to text, graphics, images, voice recordings, and other material is for informational purposes only and should not be taken as professional medical advice or a substitute for professional medical advice, diagnosis, or treatment. Although we strive to provide accurate general information, you should not rely solely on this information. Always seek health advice from your physician or other qualified healthcare personnel and never disregard professional medical advice or delay in seeking medical advice because of information read on the website. ABVC products are intended solely for investigational use and have not been approved by the Food and Drug Administration. Furthermore, there may be forward-looking statements contained in the content that are based on management’s beliefs and assumptions on currently available information. Forward-Looking statements include information concerning our current and future financial performance, business plans and objectives, current and future clinical and preclinical development activities, timing and success of our ongoing and planned clinical trials and related data, the timing of announcements, updates and results of our clinical trials and related data, our ability to obtain and maintain regulatory approval, the potential therapeutic benefits and economic value of our product candidates, competitive position, industry environment, and potential market opportunities. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” and similar expressions are intended to identify forward-looking statements.

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